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KMID : 1149220230310020099
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Korean Journal of Oriental Medical Prescription
2023 Volume.31 No. 2 p.99 ~ p.109
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Anti-inflammatory effect of Sihosogan-tang via inhibition of NF-κB and MAPK cascade
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Jin Hyo-Jeong
Park Sang-Mi
Kim Ye-Lim
Byun Sung-Hui
Kim Sang-Chan
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Abstract
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Objectives : Sihosogan-tang (SST) is one of the traditional herbal formula and also one of the Korean medical insurance medicines. It commonly used in the treatment of hepatitis, chronic gastritis, intercostal neuralgia, pleurisy, and depression in East Asia. In the present study, we have demonstrated the anti-inflammatory effects of SST in macrophage cell line.
Methods : To investigate mechanism of the anti-inflammatory effect of SST, we examined the productions of nitric oxide (NO) and pro-inflammatory cytokines, and the expressions of inducible NO synthase (iNOS), nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) on RAW 264.7 cells activated by LPS.
Results : SST significantly inhibited the expression of iNOS increased by LPS, and also significantly inhibited the production of NO. In addition, SST significantly inhibited pro-inflammatory cytokines such as TNF-α and interleukines. SST inhibited the expression of NF-κB and MAPK activation.
Conclusions : These results suggest that SST ameliorates inflammatory response in LPS-activated RAW 264.7 cells through the inhibition of the NF-κB and MAPK pathway. Therefore, this study supplies objective evidence for the anti-inflammatory effect of SST.
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KEYWORD
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Sihosogan-tang (SST), Chaihu Shugan Decoction, anti-inflammation, NF-κB, MAPK
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